Intertemporal choice in Parkinson's disease
Identifieur interne : 001608 ( Main/Exploration ); précédent : 001607; suivant : 001609Intertemporal choice in Parkinson's disease
Auteurs : Maria Milenkova [Allemagne, Bulgarie] ; Bahram Mohammadi [Allemagne] ; Katja Kollewe [Allemagne] ; Christoph Schrader [Allemagne] ; Anja Fellbrich [Allemagne] ; Matthias Wittfoth [Allemagne] ; Reinhard Dengler [Allemagne] ; Thomas F. Münte [Allemagne]Source :
- Movement Disorders [ 0885-3185 ] ; 2011-09.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Aged, Choice Behavior (drug effects), Choice Behavior (physiology), Discounting, Dopamine Agonists (pharmacology), Dopamine Agonists (therapeutic use), Dopamine agonist, Female, Humans, Impulse Control Disorders (drug therapy), Impulse Control Disorders (etiology), Male, Middle Aged, Nervous system diseases, Neuropsychological Tests, Parkinson Disease (complications), Parkinson Disease (drug therapy), Parkinson Disease (physiopathology), Parkinson disease, Parkinson's disease, Pathological gambling, Reward, Risk factor, delay discounting, dopamine agonists, intertemporal choice, pathological gambling, risk taking.
- MESH :
- chemical , pharmacology : Dopamine Agonists.
- complications : Parkinson Disease.
- drug effects : Choice Behavior.
- drug therapy : Impulse Control Disorders, Parkinson Disease.
- etiology : Impulse Control Disorders.
- physiology : Choice Behavior.
- physiopathology : Parkinson Disease.
- chemical , therapeutic use : Dopamine Agonists.
- Aged, Female, Humans, Male, Middle Aged, Neuropsychological Tests, Reward.
Abstract
The administration of dopamine agonists in Parkinson's disease has been associated with impulse control disorders, in particular, pathological gambling. In the present investigation, 17 patients with Parkinson's disease without impulse control disorders and 17 matched control participants were offered choices between monetary rewards (ranging between 11 and 80 euros) available immediately and larger rewards (between 25 and 85 euros) available after delays ranging from 7 to 186 days. Participants had a 1‐in‐6 chance of winning a reward that they chose on 1 randomly selected trial. Assuming a hyperbolic discounting model, k values were estimated from the pattern of participants' choices. Patients were tested twice, once on dopamine agonist medication and once after 12 hours without medication. Patients showed a considerably steeper discounting function than healthy controls independent of medication status, with k values more than 3 times larger than those of controls. This study shows that patients with Parkinson's disease without clinically apparent impulse control disorders nevertheless tend to make impulsive decisions in intertemporal monetary choice. The lack of difference between sessions could be a result either of the persistent effects of dopaminergic therapy or hint at a genuine medication‐independent change in intertemporal choice behavior in Parkinson's disease. This needs to be addressed in further studies. The paradigm used is easy to apply and should be used more extensively to describe decision behavior in Parkinson's disease. © 2011 Movement Disorder Society
Url:
DOI: 10.1002/mds.23756
Affiliations:
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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2011-09">2011-09</date><biblScope unit="vol">26</biblScope><biblScope unit="issue">11</biblScope><biblScope unit="page" from="2004">2004</biblScope><biblScope unit="page" to="2010">2010</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">F6E4179E813CCFDB468B5FE26A27DC1D95C159EA</idno><idno type="DOI">10.1002/mds.23756</idno><idno type="ArticleID">MDS23756</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Choice Behavior (drug effects)</term><term>Choice Behavior (physiology)</term><term>Discounting</term><term>Dopamine Agonists (pharmacology)</term><term>Dopamine Agonists (therapeutic use)</term><term>Dopamine agonist</term><term>Female</term><term>Humans</term><term>Impulse Control Disorders (drug therapy)</term><term>Impulse Control Disorders (etiology)</term><term>Male</term><term>Middle Aged</term><term>Nervous system diseases</term><term>Neuropsychological Tests</term><term>Parkinson Disease (complications)</term><term>Parkinson Disease (drug therapy)</term><term>Parkinson Disease (physiopathology)</term><term>Parkinson disease</term><term>Parkinson's disease</term><term>Pathological gambling</term><term>Reward</term><term>Risk factor</term><term>delay discounting</term><term>dopamine agonists</term><term>intertemporal choice</term><term>pathological gambling</term><term>risk taking</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Dopamine Agonists</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Choice Behavior</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Impulse Control Disorders</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Impulse Control Disorders</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Choice Behavior</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Dopamine Agonists</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Neuropsychological Tests</term><term>Reward</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Actualisation</term><term>Facteur risque</term><term>Jeu pathologique</term><term>Maladie de Parkinson</term><term>Pathologie du système nerveux</term><term>Stimulant dopaminergique</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The administration of dopamine agonists in Parkinson's disease has been associated with impulse control disorders, in particular, pathological gambling. In the present investigation, 17 patients with Parkinson's disease without impulse control disorders and 17 matched control participants were offered choices between monetary rewards (ranging between 11 and 80 euros) available immediately and larger rewards (between 25 and 85 euros) available after delays ranging from 7 to 186 days. Participants had a 1‐in‐6 chance of winning a reward that they chose on 1 randomly selected trial. Assuming a hyperbolic discounting model, k values were estimated from the pattern of participants' choices. Patients were tested twice, once on dopamine agonist medication and once after 12 hours without medication. Patients showed a considerably steeper discounting function than healthy controls independent of medication status, with k values more than 3 times larger than those of controls. This study shows that patients with Parkinson's disease without clinically apparent impulse control disorders nevertheless tend to make impulsive decisions in intertemporal monetary choice. The lack of difference between sessions could be a result either of the persistent effects of dopaminergic therapy or hint at a genuine medication‐independent change in intertemporal choice behavior in Parkinson's disease. This needs to be addressed in further studies. The paradigm used is easy to apply and should be used more extensively to describe decision behavior in Parkinson's disease. © 2011 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Bulgarie</li></country><region><li>Basse-Saxe</li><li>Sofia-ville (oblast)</li></region><settlement><li>Hanovre</li><li>Sofia</li></settlement></list><tree><country name="Allemagne"><region name="Basse-Saxe"><name sortKey="Milenkova, Maria" sort="Milenkova, Maria" uniqKey="Milenkova M" first="Maria" last="Milenkova">Maria Milenkova</name></region><name sortKey="Dengler, Reinhard" sort="Dengler, Reinhard" uniqKey="Dengler R" first="Reinhard" last="Dengler">Reinhard Dengler</name><name sortKey="Fellbrich, Anja" sort="Fellbrich, Anja" uniqKey="Fellbrich A" first="Anja" last="Fellbrich">Anja Fellbrich</name><name sortKey="Kollewe, Katja" sort="Kollewe, Katja" uniqKey="Kollewe K" first="Katja" last="Kollewe">Katja Kollewe</name><name sortKey="Mohammadi, Bahram" sort="Mohammadi, Bahram" uniqKey="Mohammadi B" first="Bahram" last="Mohammadi">Bahram Mohammadi</name><name sortKey="Munte, Thomas F" sort="Munte, Thomas F" uniqKey="Munte T" first="Thomas F." last="Münte">Thomas F. Münte</name><name sortKey="Schrader, Christoph" sort="Schrader, Christoph" uniqKey="Schrader C" first="Christoph" last="Schrader">Christoph Schrader</name><name sortKey="Wittfoth, Matthias" sort="Wittfoth, Matthias" uniqKey="Wittfoth M" first="Matthias" last="Wittfoth">Matthias Wittfoth</name></country><country name="Bulgarie"><region name="Sofia-ville (oblast)"><name sortKey="Milenkova, Maria" sort="Milenkova, Maria" uniqKey="Milenkova M" first="Maria" last="Milenkova">Maria Milenkova</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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